| BOSTON RED SOX | VS | NEW YORK YANKEES | | April 4th, 2010 8:05 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | NEW YORK YANKEES | | April 6th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | NEW YORK YANKEES | | April 7th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | April 16th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | April 17th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | April 18th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | April 19th, 2010 11:05 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TEXAS RANGERS | | April 20th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TEXAS RANGERS | | April 21st, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TEXAS RANGERS | | April 22nd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | April 23rd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | April 24th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | April 25th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES ANGELS OF ANAHEIM | | May 3rd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES ANGELS OF ANAHEIM | | May 4th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES ANGELS OF ANAHEIM | | May 5th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES ANGELS OF ANAHEIM | | May 6th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | NEW YORK YANKEES | | May 7th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | NEW YORK YANKEES | | May 8th, 2010 12:00 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | NEW YORK YANKEES | | May 9th, 2010 8:05 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | May 10th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | May 11th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | May 12th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | MINNESOTA TWINS | | May 19th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | MINNESOTA TWINS | | May 20th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | KANSAS CITY ROYALS | | May 27th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | KANSAS CITY ROYALS | | May 28th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | KANSAS CITY ROYALS | | May 29th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | KANSAS CITY ROYALS | | May 30th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | OAKLAND ATHLETICS | | June 1st, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | OAKLAND ATHLETICS | | June 2nd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | OAKLAND ATHLETICS | | June 3rd, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | PHILADELPHIA PHILLIES | | June 11th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | PHILADELPHIA PHILLIES | | June 12th, 2010 12:00 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | PHILADELPHIA PHILLIES | | June 13th, 2010 12:00 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | ARIZONA DIAMONDBACKS | | June 15th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | ARIZONA DIAMONDBACKS | | June 16th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | ARIZONA DIAMONDBACKS | | June 17th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES DODGERS | | June 18th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES DODGERS | | June 19th, 2010 12:00 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES DODGERS | | June 20th, 2010 12:00 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | June 29th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | June 30th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | July 2nd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | July 3rd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | July 4th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TEXAS RANGERS | | July 15th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TEXAS RANGERS | | July 16th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TEXAS RANGERS | | July 17th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TEXAS RANGERS | | July 18th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | DETROIT TIGERS | | July 30th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | DETROIT TIGERS | | July 31st, 2010 12:00 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | DETROIT TIGERS | | August 1st, 2010 12:00 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | CLEVELAND INDIANS | | August 2nd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | CLEVELAND INDIANS | | August 3rd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | CLEVELAND INDIANS | | August 4th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | CLEVELAND INDIANS | | August 5th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES ANGELS OF ANAHEIM | | August 17th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES ANGELS OF ANAHEIM | | August 18th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | LOS ANGELES ANGELS OF ANAHEIM | | August 19th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | August 20th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | August 21st, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | August 22nd, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | SEATTLE MARINERS | | August 23rd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | SEATTLE MARINERS | | August 24th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | SEATTLE MARINERS | | August 25th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | CHICAGO WHITE SOX | | September 3rd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | CHICAGO WHITE SOX | | September 4th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | CHICAGO WHITE SOX | | September 5th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | September 6th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | September 7th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TAMPA BAY RAYS | | September 8th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | September 17th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | September 18th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | TORONTO BLUE JAYS | | September 19th, 2010 1:35 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | September 20th, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | September 21st, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | BALTIMORE ORIOLES | | September 22nd, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | NEW YORK YANKEES | | October 1st, 2010 7:10 PM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | NEW YORK YANKEES | | October 2nd, 2010 12:00 AM Fenway Park, Boston, MA | |
| BOSTON RED SOX | VS | NEW YORK YANKEES | | October 3rd, 2010 1:35 PM Fenway Park, Boston, MA | |